Acetic Acid → HCID 67582831, compound

HRID 1416481Notes

Reaction equation

HRID 1416481 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[C:21]([OH:24])(=[O:23])[CH3:22]>CO>[C:21]([OH:24])(=[O:23])[CH3:22].[OH:1][CH2:2][CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 53778010HCID 53778010, compound

Product 1

HCID 67582831HCID 67582831, compoundYield 13.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-[(2-hydroxyethyl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 42) (1.2 g) in methanol (20 ml) is added acetic acid (0.3 g), and the mixture is evaporated to dryness under reduced pressure. The residue is recrystallized from acetonitrile to give 4-[(2-hydroxyethyl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.2 g) as crystals.

Workup

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. customThe residue is recrystallized from acetonitrile

Sources & evidence

ORD record
ord-9252efe449274f2187141db7bdf82941
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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