Chloroform → HCID 53831111, compound

Participants

Reaction Steps

To a solution of 2-[4-(benzyloxycarbonyl)piperazin-1-yl]-4-[(RS)-(2,3-dihydroxypropyl)oxy]quinazoline (930 mg) in methanol (10 ml) is added 10% palladium/carbon (280 mg), and the mixture is stirred under hydrogen atmosphere and under atmospheric pressure at room temperature for 15 hours. To the reaction mixture is added chloroform (30 ml), and the mixture is filtered, and the filtrate is evaporated to dryness under reduced pressure. The residue is dissolved in methanol-chloroform, and the solution is filtered, and the filtrate is evaporated to dryness under reduced pressure. The residue is dissolved in acetone, and the solution is allowed to stand at room temperature, and the precipitated crystals are separated by filtration to give 4-[(RS)-(2,3-dihydroxypropyl)oxy]-2-(1-piperazinyl)quinazoline (355 mg) as crystals.

Provenance & Evidence