Acetic Acid → HCID 67582997, compound

Participants

Reaction Steps

4-[(2S,3S)-(3-Hydroxybutan-2-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 48) (650 mg) is dissolved in a solution of acetic acid (147 mg) in acetone (20 ml), and the mixture is filtered. The filtrate is evaporated to dryness under reduced pressure, and the residue is dissolved in ethyl acetate (8 ml), and the solution is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[(2S,3S)-(3-hydroxybutan-2-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (546 mg) as crystals.

Provenance & Evidence