Acetone → HCID 67582965, compound

Participants

Reaction Steps

4-[(2R,3R)-(3-Hydroxybutan-2-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 50) (600 mg) is dissolved in acetone (30 ml), and the mixture is filtered. To the filtrate is added acetic acid (135 mg), and the mixture is evaporated to dryness under reduced pressure, and the residue is dissolved in ethyl acetate (6 ml), and the solution is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[(2R,3R)-(3-hydroxybutan-2-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (443 mg) as crystals.

Provenance & Evidence