HCID 67582830, compound → HCID 54302338, compound

Participants

Reaction Steps

To a solution of 2-[4-(benzyloxycarbonyl)piperazin-1-yl]-4-[(2RS,3RS)-(2,3-dihydroxybutan-1-yl)oxy]quinazoline (950 mg) in methanol (21 ml) is added 10% palladium/carbon (109 mg), and the mixture is stirred under hydrogen atmosphere and under atmospheric pressure at room temperature for 8 hours. The reaction mixture is filtered, and the filtrate is evaporated to dryness under reduced pressure, and the residue is crystallized from acetone-diethyl ether. The crystals thus obtained are recrystallized from ethanol - diethyl ether to give 4-[(2RS,3RS)-(2,3-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (235 mg) as crystals.

Provenance & Evidence