Hydrochloride methanol → HCID 67581967, compound

Participants

Reaction Steps

To a solution of 4-[(3R)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 59) (1.90 g) in methanol (38 ml) is added 2N HCl-methanol (3.59 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is washed with acetone and recrystallized from methanol-acetone to give 4-[(3R)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (1.61 g) as crystals.

Provenance & Evidence