Hydrochloride methanol → HCID 67583545, compound

HRID 1416507Notes

Reaction equation

HRID 1416507 reaction equation
[OH:1][C@@H:2]([C@H:21]([OH:24])[CH2:22][OH:23])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[ClH:25].CO>CO>[ClH:25].[OH:1][C@@H:2]([C@H:21]([OH:24])[CH2:22][OH:23])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 54235254HCID 54235254, compound

Product 1

HCID 67583545HCID 67583545, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-[(2R,3R)-(2,3,4-Trihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf Example 64) (0.5 g) is dissolved in methanol (40 ml), and thereto is added 2N HCl-methanol (0.82 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is recrystallized from ethanol to give 4-[(2R,3R)-(2,3,4-trihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (0.14 g).

Workup

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. customThe resulting residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-06f34af567b245959df6c6b0b9bbff79
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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