HCID 67583605, compound → HCID 53831110, compound

Participants

Reaction Steps

2-[4-(Benzyloxycarbonyl)piperazin-1-yl]-4-[(2R)-(2,3-dihydroxypropan-1-yl)oxy]quinazoline (5.8 g) is dissolved in methanol (50 ml), and thereto is added 10% palladium/carbon (0.6 g), and the mixture is stirred under hydrogen atmosphere and under atmospheric pressure at room temperature overnight. The reaction mixture is filtered, and the filtrate is evaporated to dryness under reduced pressure, and the residue is recrystallized from methanol to give 4-[(2R)-(2,3-dihydroxypropan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (1.4 g).

Provenance & Evidence