Succinic Acid → L-Aspartic Acid

HRID 1416510Notes

Reaction equation

HRID 1416510 reaction equation
[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[NH4+:9].C(O)(=O)CCC(O)=O.[OH-].[Na+]>>[NH2:9][C@H:2]([C:1]([OH:8])=[O:7])[CH2:3][C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 1110Succinic AcidHCID 14798Sodium HydroxideHCID 1159344144742-89-4

Product 1

HCID 5960L-Aspartic Acid

Procedure

Monoammonium maleate (3.00 g of 94% wet salt, 0.0212 mole) and succinic acid (.[.0,278.]. 0.278 g, 0.0024 mole) were thoroughly mixed together and then were reacted as in Example 2 and 3 by heating in a convection oven at .[.230°240°.]. 230°-240° C. for 40 minutes. A brittle, red-brown solid was obtained which weighed .[.2,204.]. 2.204 g. Hydrolysis of this product with sodium hydroxide produced an aspartic acid copolymer having molecular weights by GPC of Mw 1717, Mn 1016, Mw/Mn 1.69.

Workup

  1. customwere reacted as in Example 2 and 3
  2. temperatureby heating in a convection oven at .[.230°240°
  3. customA brittle, red-brown solid was obtained which

Sources & evidence

ORD record
ord-f61262e80bac4844984e254cdd14dc0e
Source dataset
uspto-grants-1999_06
Patent number
USRE036234

Reaction notes

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