HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2-Cyano-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Methyl cyanoacetate | HCID 7747 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-cyano-3-methylbutanoate | HCID 557651 | — |
| Reactant | N-(2-cyano-3-methylbutanoyl)urea | HCID 9793952 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-Cyano-3-methylbutanoic acid | HCID 255338 | — |
Reaction Steps
The starting compound, N-(2-cyano-3-methylbutanoyl)urea, is a known compound and can be obtained by, for example, reacting methyl cyanoacetate and acetone, hydrolyzing the resulting methyl 2-cyano-3-methylbutyrate with an aqueous sodium hydroxide solution, treating said reaction mixture with sulfuric acid to give 2-cyano-3-methylbutyric acid and heating this compound in the presence of urea and acetic anhydride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05914399 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-e8cfa649c5414951b35cfad62f5a74ac |
| Source note | uspto-grants-1999_06 |