Dimethylformamide → HCID 53916846, compound

Participants

Reaction Conditions

Reaction Steps

A 132 mg sample of the compound from step 50a above was dissolved 4 mL of a 6:1 solution of DMF:H2O, 240 mg of NaCN was added, and the reaction mixture was stirred at 95° C. for 16 hours. The solvent was removed, and the residue was purified by column chromatography on silica gel, eluting with 10:1 chloroform:methanol to afford 62 mg of the title compound. MS (DCI/NH3) m/e: 232 (M+H)+. 1H NMR (CDCl3, 300 MHz) δ: 8.34 (m, 1H), 8.28 (m, 1H); 7.30-7.20 (m, 2H), 4.28-4.06 (m, 2H), 3.05-2.72 (m, 5H), 2.65-2.52 (br s, 3H), 2.42-2.25 (m, 1H), 2.23-2.0 (m, 2H).

Provenance & Evidence