Ammonia → HCID 86754120, compound

Participants

Reaction Steps

Following the procedures described in Example 45 steps a-c, substituting (R)-1-t-butoxycarbonyl-2-pyrrolidinemethanol for the (S)-1-t-butoxycarbonyl-2-pyrrolidinemethanol of step 45a thereof, the title compound was prepared. mp 157-159° C. MS (DCI/NH3) m/e: 213/215 (M+H)+ and 230/232 (M+NH4)+. 1H NMR (D2O, 300 MHz) δ: 8.10 (d, J=3.0 Hz, 1H), 7.53-7.43 (m, 2H), 4.45 (dd, J=10.7, 7.7 Hz, 1H), 4.15-4.08 (m, 1H), 3.41 (t, J=7.2 Hz, 2H), 2.34-1.88 (m, 4H). Anal. Calc. for C10H14Cl2N2O·0.3 HCl: C, 46.18; H, 5.54; N, 10.77; Found C, 46.35; H, 5.51; N, 10.66.

Provenance & Evidence