HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dibromopyridine 1-oxide → 3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dibromopyridine 1-oxide | HCID 620003 | — |
| Reactant | (2S)-1-Methyl-2-pyrrolidinemethanol | HCID 643492 | — |
| Product | 3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide | HCID 21309672 | — |
Reaction Steps
A sample of 3,5-dibromopyridine-N-oxide (prepared according to the method of Y. Tamura et al., Heterocycles, 15:871-874 (1981)) is reacted with (S)-(-)-1-methyl-2-pyrrolidinemethanol according to the procedure of Example 3a, and the product is purified by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05914328 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-98d2684187894a2386ba0cd1a8fede10 |
| Source note | uspto-grants-1999_06 |