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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1416655Generated: October 30, 2026

Sodium Cyanide → 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5-cyan-pyridine-N-oxide

https://huagongshe.com/reaction/1416655

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium CyanideHCID 8929—
Reactant3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxideHCID 21309672—
SolventWaterHCID 962—
SolventDimethylformamideHCID 6228—
Product3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5-cyan-pyridine-N-oxideHCID 54148128—

Reaction Steps

A sample of 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5bromo-pyridine-N-oxide, from Example 98a above, is reacted with sodium cyanide in DMF and water according to standard procedures. The solvents are removed, and the product is extracted, then purified by chromatography on silica gel.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05914328
Source datasetuspto-grants-1999_06
ORD IDord-64dc8a8b20fc45a398596923958089ce
Source noteuspto-grants-1999_06