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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1416723Generated: October 26, 2026

Hydrochloric Acid → 5-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(2-butoxy-ethyl) ester hydrochloride salt

https://huagongshe.com/reaction/1416723

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2-ButoxyethanolHCID 8133—
Reactant5-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acidHCID 4281355—
Product5-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(2-butoxy-ethyl) ester hydrochloride saltHCID 86754128—

Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-butoxyethanol accord-ing to the procedure of Example 1 as a colorless oil; 1H NMR (300 MHz, CDCl3): δ 0.78-0.93 (m, 6H), 1.15-1.78 (m, 12H), 2.70-3.62 (brm, 5H), 3.31-3.47 (m, 4H), 3.57-3.73 (m, 4H), 4.29-4.53 (m, 4H), 5.47-5.57 (brs, 1H), 6.70-6.95 (m, 3H), 7.20-7.49 (m, 4H); MS (ES) m/z (relative intensity): 622 (M+ -HCl, 20), 214 (10), 158 (10).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05914339
Source datasetuspto-grants-1999_06
ORD IDord-cbe10f7d89224d03a6a49e0fb096b9cb
Source noteuspto-grants-1999_06