Benzyl Alcohol → HCID 67589379, compound

HRID 1416727Notes

Reaction equation

HRID 1416727 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:29])[CH2:9][NH:10][CH:11]([CH3:28])[CH2:12][C:13]2[CH:27]=[CH:26][C:16]3[O:17][C:18]([C:23]([OH:25])=[O:24])([C:20]([OH:22])=[O:21])[O:19][C:15]=3[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:30](O)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[ClH:1].[CH2:30]([O:24][C:23]([C:18]1([C:20]([O:22][CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)=[O:21])[O:17][C:16]2[CH:26]=[CH:27][C:13]([CH2:12][CH:11]([NH:10][CH2:9][CH:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[OH:29])[CH3:28])=[CH:14][C:15]=2[O:19]1)=[O:25])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 244Benzyl AlcoholHCID 42813555-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid

Product 1

HCID 67589379HCID 67589379, compound

Procedure

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and benzyl alcohol according to the procedure of Example I as a gummy white solid: 1H NMR (300 MHz, CDCl3): δ 1.26-1.32 (m, 3H), 2.76 (brt, 1H), 3.01-3.21 (brm, 2H), 3.36-3.49 (brm, 2H), 5.24 (s, 4H), 5.41 (d, J=9.5 Hz, 1H), 6.70-6.88 (m, 3H), 7.12-7.44 (complex m, 14H), 8.70-8.83 (brs, 1H), 9.95-10.10 (brs, 1H); MS (ES) m/z (relative intensity): 602 (M+, 100).

Sources & evidence

ORD record
ord-8065fded333242308b289a79313bda57
Source dataset
uspto-grants-1999_06
Patent number
US05914339

Reaction notes

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