1-Phenylethanol → HCID 9895469, compound

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Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 1-phenylethanol as a gummy tan solid according to the procedure of Example 1, leaving out the final HCl(g) /Et2O hydrochloride salt forming step: 1H NMR (300 MHz, CDCl3): δ 0.90-1.22 (m, 6H), 1.30-1.61 (m, 6H), 2.39-2.70 (brm, 1H), 2.83-3.19 (brm, 2H), 3.20-3.50 (brm, 2H), 5.15-5.35 (brs, 1H), 5.90-6.02 (brm, 1H), 6.45-6.82 (m, 3H), 7.11-7.40 (m, 4H), 8.64 (brs, 1H), 9.45 (brs, 1H); MS (ES) m/z (relative intensity): 630 (M+, 100).

Provenance & Evidence