Heptanol → HCID 9960649, compound

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Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 1-heptanol as a brown gum according to the procedure of Example 1, leaving out the final HCl(g) /Et2O hydrochloride salt forming step: 1H NMR (300 MHz, CDCl3): δ 0.80-0.92 (m, 6H), 1.23-1.40 (brm, 19H), 1.60-1.75 (m, 4H), 2.80 (t, J=8.8 Hz, 1H), 3.05-3.30 (brm, 2H), 3.38-3.50 (m, 2H), 4.27 (q, J=6.7 Hz, 4H), 5.43 (d, J=8.4 Hz, 1H), 6.72-6.90 (m, 4H), 7.20-7.33 (m, 2H), 7.44 (s, 1H), 8.70 (brs, 1H), 10.10 (brs, 1H); MS (ES) m/z (relative intensity): 618 (M+, 100).

Provenance & Evidence