1-Dodecanol → Ether hydrochloride

HRID 1416737Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:29])[CH2:9][NH:10][CH:11]([CH3:28])[CH2:12][C:13]2[CH:27]=[CH:26][C:16]3[O:17][C:18]([C:23]([OH:25])=[O:24])([C:20]([OH:22])=[O:21])[O:19][C:15]=3[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:30](O)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>>[CH2:30]([O:24][C:23]([C:18]1([C:20]([O:22][CH2:41][CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH3:30])=[O:21])[O:17][C:16]2[CH:26]=[CH:27][C:13]([CH2:12][CH:11]([NH:10][CH2:9][CH:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[OH:29])[CH3:28])=[CH:14][C:15]=2[O:19]1)=[O:25])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].[O:17]([CH2:18][CH3:20])[CH2:16][CH3:15].[ClH:1]

Participants

Reactant 2

HCID 81931-Dodecanol

HCID 42813555-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid

Product 2

HCID 10953452Ether hydrochloride

HCID 53637429HCID 53637429, compound

Procedure

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 1-dodecanol as a brown gum according to the procedure of Example 1, leaving out the final HCl(g) /Et2O hydrochloride salt forming step: 1H NMR (300 MHz, CDCl3): δ 0.88 (t, J=6.8 Hz, 9H), 1.20-1.40 (m, 30H), 1.51-1.60 (m, 4H), 1.62-1.73 (m, 4H), 2.75-2.85 (m, 1H), 3.05-3.25 (m, 2H), 3.35-3.52 (m, 2H), 4.28 (t, J=6.8 Hz, 4H), 5.45 (d, J=8.8 Hz, 1H), 6.60-6.90 (m, 3H), 7.17-7.40 (m, 3H), 7.43 (s, 1H), 8.78 (brs, 1H), 10.05 (brs, 1H); MS (ES) m/z (relative intensity): 594 (M+, 100).

Sources & evidence

ORD record: ord-b524cf01cf7842f2b07823209415d74f
Source dataset: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05914339

Reaction notes

Loading…