Isopropylethanediol → Ether hydrochloride

Participants

Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-isopropoxyethanol as a brown solid according to the procedure of Example 1, leaving out the final HCl(g) /Et2O hydrochloride salt forming step: 1H NMR (300 MHz, CDCl3): δ 1.11 (d, J=6.1 Hz, 12H), 1.30 (d, J=6.2 Hz, 3H), 2.79 (t, J=8.7 Hz, 1H), 3.06-3.28 (m, 2H), 3.40-3.60 (m, 2H), 3.62-3.70 (complexm, 4H), 3.90-4.12 (brm, 2H), 4.35-4.45 (complexm, 4H), 5.43 (d, J=8.7 Hz, 1H), 6.61-6.90 (m, 3H), 7.11-7.32 (m, 3H), 7.44 (m, 1H), 8.70 (brs, 1H), 9.92 (brs, 1H); MS (ES) m/z (relative intensity): 758 (M+, 30), 546 (100).

Provenance & Evidence