Acetic acid, bromo-, propyl ester → 5-(2-{tert-Butoxycarbonyl-[2-(3-chloro-phenyl)-2-hydroxy-ethyl]-amino}-propyl)-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-propoxycarbonylmethyl ester

Participants

Reaction Steps

The title compound was prepared from 5-(2-{tert-butoxycarbonyl-[2-(3-chloro-phenyl)-2-hydroxy-ethyl]-amino}-propyl)-benzo[1,3]dioxole-2,2-dicarboxylic acid and propyl 2-bromoacetate according to the procedure of Example 24, step 3 as a colorless oil: 1H NMR (300 MHz, CDCl3): δ 0.91 (t, J=7.4 Hz, 6H), 1.21 (d, J=6.9 Hz, 3H), 1.40 (s, 9H), 1.55-1.72 (m, 4H), 2.47-2.70 (m, 1H), 3.05-3.17 (m, 1H), 3.46-3.60 (m, 1H), 4.11 (t, J=6.6 Hz, 4H), 4.70-4.85 (m, 4H), 5.47 (s, 1H), 6.60-6.92 (m, 3H), 7.20-7.35 (m, 3H), 7.41 (s, 1H); MS (ES) m/z (relative intensity): 722 (M+, 100).

Provenance & Evidence