Isopropyl bromoacetate → 5-(2-{tert-Butoxycarbonyl-[2-(3-chloro-phenyl)-2-hydroxy-ethyl]-amino}-propyl)-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-isopropoxycarbonyl-methyl ester

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The title compound was prepared from 5-(2-{tert-butoxycarbonyl-[2-(3-chloro-phenyl)-2-hydroxy-ethyl]-amino}-propyl)-benzo[1,3]dioxole-2,2-dicarboxylic acid and isopropyl 2-bromoacetate according to the procedure of Example 24, step 3 as a colorless oil: 1H NMR (300 MHz, CDCl3): δ 1.15-1.30 (m, 15H), 1.40 (s, 9H), 2.45-2.70 (m, 2H), 3.06-3.15 (m, 1H), 3.45-3.60 (m, 1H), 4.05-4.18 (m, 2H), 4.70-4.80 (m, 4H), 5.06 (sept, J=6.3 Hz, 2H), 5.46 (brs, 1H), 6.60-6.90 (m, 3H), 7.20-7.35 (m, 3H), 7.41 (s, 1H).; MS (ES) m/z (relative intensity): 722 (M+, 100).

Provenance & Evidence