Hydrochloric Acid → HCID 54406209, compound

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Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-trimethylsilylethanol according to the procedure of Example 30 as a white foam (HCl salt); 1H NMR (CDCl3) δ 0.03 (s, 18H), 1.06 (t, J=8.6 Hz, 4H), 1.33 (bs, 3H), 1.90 (bs, 1H), 2.80 (bs, 1H), 3.18 (bs, 2H), 3.48 (bs, 2H), 4.37 (t, J=8.6 Hz, 4 H), 5.45 (bs, 1H), 6.80 (m, 3H), 7.26 (m, 2H), 7.43 (s, 1H), 8.70 (bs, 1H), 10.10 (bs, 1H); IR (KBr): 1763 cm-1 (C=O); MS (ES) m/z 622 (MH+); [α]D25 -23° (c, 1.0, CHCl3). Anal. Calcd. for C30H44ClNO7Si2 ·HCl: C, 54.70; H, 6.88; N, 2.13; Cl, 10.76; Si, 8.53. Found: C, 53.96; H, 7.05; N, 1.86; Cl, 8.84; Si, 10.33.

Provenance & Evidence