HCID 10053575, compound → HCID 15894405, compound

HRID 1416766Notes

Reaction equation

HRID 1416766 reaction equation
[CH3:1][CH:2]([CH3:39])[CH2:3][CH2:4][O:5][C:6]([C:8]1([C:31]([O:33]CCC(C)C)=[O:32])[O:12][C:11]2[CH:13]=[CH:14][C:15]([CH2:17][C@H:18]([NH:20][CH2:21][C@@H:22]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[CH:25]=3)[OH:23])[CH3:19])=[CH:16][C:10]=2[O:9]1)=[O:7]>C(Cl)(Cl)Cl>[CH3:1][CH:2]([CH3:39])[CH2:3][CH2:4][O:5][C:6]([C:8]1([C:31]([OH:33])=[O:32])[O:12][C:11]2[CH:13]=[CH:14][C:15]([CH2:17][C@H:18]([NH:20][CH2:21][C@@H:22]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[CH:25]=3)[OH:23])[CH3:19])=[CH:16][C:10]=2[O:9]1)=[O:7]

Participants

3

Reactant 1

HCID 10053575HCID 10053575, compound

Product 1

HCID 15894405HCID 15894405, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from 5-{(2R)-2-[(2R)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(3-methylbutyl)ester according to the procedure of Example 22 as an off-white solid; 1H NMR (DMSO) δ 0.80-0.85 (m, 6H), 1.02-1.09 (m, 3H), 1.45 (q, 2H), 1.55-1.70 (m, 1H), 3.01-3.05 (m, 2H), 3.15-3.25 (m, 1H), 3.26-3.40 (m, 2H), 4.15 (t, 2H), 5.00-5.08 (m, 1H), 6.45 (bs, 1H), 6.55-6.65 (m, 1H), 6.75-6.90 (m, 2H), 7.45-7.49 (m, 5H), 7.51 (s, 1H); IR (Kbr): 3394 cm-1 (--OH), 1651 cm-1 (C=O); MS (ES) m/z 492.0 (MH+); [α]D25 -22° (c, 1.0, CHCl3). Anal. Calcd. for C25H30ClNO7 : C, 61.04; H, 6.15; N, 2.85; Cl, 7.20. Found: C, 59.80; H, 6.10; N, 2.89; Cl, 7.10.

Sources & evidence

ORD record
ord-8632bc2096fd4cacb7783616ff85e1a2
Source dataset
uspto-grants-1999_06
Patent number
US05914339

Reaction notes

Loading…