Hydrochloric Acid → HCID 86754132, compound

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Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and adamantan-1-ylmethanol according to the procedure of Example 1 as a white solid (HCl salt); 1H NMR (CDCl3) δ 1.25 (m, 2H), 1.35 (d, 3H), 1.51 (s, 12H), 1.55-1.61 (m, 2H), 1.61-1.67 (m, 4H), 1.67-1.75 (m, 6H), 1.97 (s, 4H), 3.20 (s, 2H), 3.42-3.49 (m, 2H), 3.88 (s, 4H), 4-11-4.16 (q, 1H), 5.45 (bd, 1H), 5.65 (bd, 1H), 6.75 (m, 1H), 6.78-6.89 (m, 2H), 7.23-7.30 (m, 3H), 7.44 (s, 1H), 8.74 (bs, 1H), 10.115 (bs, 1H); IR (KBr) 3418 cm-1 (--OH), 1767 cm-1 (C=O); MS (ES) m/z 718.4 (MH+); [α]D25 -15° (c, 1.0, CHCl3). Anal. Calcd. for C42H52ClNO7 : C, 68.94; H, 9.22; N, 1.90; Cl, 9.40. Found: C, 67.48; H, 7.49; N, 1.48; Cl, 8.10.

Provenance & Evidence