Hydrochloric Acid → HCID 9872586, compound

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Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2,2-dimethylpropanol according to the procedure of Example 1 as an off-white foam (HCl salt); 1H NMR (CDCl3) δ 0.924 (s, 18H), 1.45 (d, 2H), 1.75 (s, 2H), 2.80 (m, 1H), 3.17 (m, 1H), 3.45 (m, 1H), 3.98 (s, 4H), 5.45-5.55 (bd, 1H), 5.63-5.67 (bs, 1H), 6.75-6.80 (m, 2H), 6.80-6.89 (m, 2H), 7.25-7.35 (m, 3H), 7.440 (s, 1H), 8.75 (bs, 1H), 10.10 (bs, 1H); IR (KBr) 3355 cm-1 (--OH), 1767 cm-1 (C=O); MS (ES) m/z 562.3 (MH+); [α]D25 -23° (c, 1.0, CHCl3). Anal. Calcd. for C30H40ClNO7 : C, 60.20; H, 6.90; N, 2.34; Cl, 11.85. Found: C, 59.74; H, 6.97; N, 2.23; Cl, 11.60.

Provenance & Evidence