Hydrochloric Acid → HCID 44300368, compound

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The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and tetrahydrofuran-3-ylmethanol according to the procedure of Example 1 as an off-white solid; 1H NMR (DMSO-d6,400 MHz) δ 1.03 (d, J=6.37 Hz, 3H, CH3), 1.5 (m, 2H, CH2), 1.9 (m, 2H, CH2), 2.6 (m, 3H, CH), 3-3.3 (m, 3H, CH, CH2), 3.4 (brs, 1H, CH), 3.6-3.7 (m, 6H, CH2), 4.1-4.15 (m, 6H, CH2), 5.09 (m, 1H, CH), 6.36 (brs, 1H, OH), 6.86 (m, 1H, Ar--H), 7.07 (m, 2H, Ar--H), 7.38-7.42 (m, 3H, Ar--H), 7.47 (s, 1H, Ar--H), 8.84 (brs, 2H, NH, NH); IR (KBr, cm-1) 3300 (OH), 2900 (NH), 1760 (CO); MS m/e 590 (M+H)+ ; Analysis for: C30H36ClNO9 ×HCl: Calc'd: C, 57.51; H, 5.95; N, 2.24; Found: C, 57.80; H, 6.30; N, 2.21.

Provenance & Evidence