Reaction Steps
The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and tetrahydropyran-2-ylmethanol according to the procedure of Example 1 as an off-white solid; 1H NMR (DMSO-d6,400 MHz) δ 1.10 (d, J=6.37 Hz, 3H, CH3), 1.1-1.2 (m, 2H, CH2), 1.3-1.6 (m, 8H, CH2), 1.7-1.8 (m, 2H, CH2), 2.6 (m, 1H, CH), 3-3.5 (m, 9H, CH, CH2), 3.8 (m, 2H, CH), 4.19-4.2 (s, s, 4H, OCH2, OCH2), 5.04 (m, 1H, CH), 6.35 (d, J=4.17 Hz, 1H, OH), 6.85 (d, J=8.13 Hz, 1H, Ar--H), 7.07 (m, 2H, Ar--H), 7.36-7.42 (m, 3H, Ar--H), 7.48 (s, 1H, Ar--H), 8.76 (brs, 1H, NH), 9.18 (brs, 1H, NH); IR (KBr, cm-1) 3400 (OH), 2900 (NH), 1760 (CO); MS m/e 618 (M+H)+ ; Analysis for: C32H40ClNO9 ×HCl: Calc'd: C, 58.72; H, 6.31; N, 2.14; Found: C, 57.97; H, 6.46; N, 2.08.
