Ethylenediamine → HCID 19701537, compound

HRID 1416907Notes

Reaction equation

HRID 1416907 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([N:12]=[C:13]=[S:14])[C:9]([CH3:15])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH2:16]([NH2:19])[CH2:17][NH2:18]>C1(C)C=CC=CC=1>[NH2:18][CH2:17][CH2:16][NH:19][C:13](=[S:14])[NH:12][C:10]1[C:9]([CH3:15])=[C:8]2[C:3]([CH:4]=[CH:5][CH:6]=[N:7]2)=[C:2]([F:1])[CH:11]=1

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 18465370HCID 18465370, compound

Product 1

HCID 19701537HCID 19701537, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 5-fluoro-7-isothiocyanato-8-methylquinoline (0.38 g) in toluene (40 mL) is added dropwise to a solution of ethylenediamine (0.78 g) in toluene (40 mL). A white precipitate is observed after the reaction stirs for 10 minutes at room temperature. The precipitate is filtered and dried in vacuo to afford 7-[N'-(2-aminoethyl)thioureido]-5-fluoro-8-methylquinoline as a white solid.

Workup

  1. filtrationThe precipitate is filtered
  2. customdried in vacuo

Sources & evidence

ORD record
ord-42dca31e0136423f824375db40849fb0
Source dataset
uspto-grants-1999_06
Patent number
US05916900

Reaction notes

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