Potassium Hydroxide → HCID 339735, compound

HRID 1416932Notes

Reaction equation

HRID 1416932 reaction equation
[C:1]([NH:9][C:10]1[N:14](C(=O)C2C=CC=CC=2)[N:13]=[C:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>>[C:1]([NH:9][C:10]1[CH:11]=[C:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[NH:13][N:14]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 9864013HCID 9864013, compound

Product 1

HCID 339735HCID 339735, compoundYield 67%

Conditions

Temperature
100 °C

Procedure

A suspension of 100 mg (0.27 mmoles) of 5-benzoylamino-3-phenyl-1-benzoylpyrazole in 4 ml of 10% (w/v) aqueous potassium hydroxide was heated in a water bath maintained at 100° C. for five minutes. During this time the reaction mixture remained a suspension. The cooled suspension was filtered and washed with water, then air-dried. There was obtained 48 mg (0.18 mmoles, 67%) of the title compound as a white solid.

Workup

  1. temperaturewas heated in a water bath
  2. filtrationThe cooled suspension was filtered
  3. washwashed with water
  4. customair-dried

Sources & evidence

ORD record
ord-f56d6178ce794907a42db79068c8b04d
Source dataset
uspto-grants-1999_06
Patent number
US05916908

Reaction notes

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