HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenyl Ether → Ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | Diethyl 2-((2-nitrophenylamino)methylene)malonate | HCID 225911 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate | HCID 21250014 | 85% |
Reaction Steps
Diethyl (2-nitroanilino)methylenemalonate (43 g) was added to refluxing diphenyl ether (600 ml). The mixture was stirred at reflux for 1.5 hours, then cooled to ambient temperature. Diethyl ether (600 ml) was added and the mixture filtered. The solid so obtained was washed with diethyl ether to give 3-ethoxycarbonyl-8-nitro-4-oxo-3,4-dihydroquinoline in 85% yield, mp 241-243° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05916898 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-a7061db6911f41bfad9bcce2cd97c594 |
| Source note | uspto-grants-1999_06 |