Methylamine → HCID 53888460, compound

Participants

Reaction Conditions

Reaction Steps

2-Chloro-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-carbonitrile (Example 7) (200 mg, 0.52 mMol) was charged with methylamine. The solution was shaken for 24 hours at 70° C. and 74 psi by a Parr Shaker. The vessel was cooled to room temperature and vented to allow excess methylamine to evaporate leaving a yellow solid. The solid was washed with methyl alcohol and recrystallized from chloroform: m.p. (DSC): 295.63° C. Anal. Calc'd. for C20H16N3O2SF (381.43): C, 62.98; H, 4.23; N, 11.02. Found: C, 62.59; H, 4.15; N. 10.77.

Provenance & Evidence