Formaldehyde → HCID 54320050, compound

Participants

Reaction Steps

Aqueous 37% formaldehyde (1 ml) was added to a stirring solution of 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methylamine [Example 32] (250 mg, 0.58 mmol) in 5 ml acetonitrile. Sodium cyanoborohydride (54 mg, 0.875 mmol) was added and the reaction mixture was stirred for 15 minutes. Two drops of acetic acid was added and the reaction mixture was stirred for 2 hours. The reaction mixture was concentrated to a paste and the titled material was purified by silica gel chromatography. Anal Calc'd. C25H29N2O3SF+0.25 H2O: C, 65.12; H, 6.45; N, 6.08. Found: C, 65.12; H, 6.46; N, 6.19.

Provenance & Evidence