HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → 5-Acetamido-2-methyl-6-nitro-8-phenyl-1,2,3,4-tetrahydro-isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline | HCID 10016010 | — |
| Reactant | 5-(4-Chlorophenyl)-N-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline | HCID 23435821 | — |
| Reactant | 2-Methyl-5-phenyl-8-nitro-1,2,3,4-tetrahydro-isoquinoline | HCID 23435858 | — |
| Product | 5-Acetamido-2-methyl-6-nitro-8-phenyl-1,2,3,4-tetrahydro-isoquinoline | HCID 23435859 | — |
Reaction Steps
2-methyl-5-phenyl-8-nitro-1,2,3,4-tetrahydro-isoquinoline mp 75-78° C. from reaction between phenyl boronic acid and 5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydro-isoquinoline. 2-methyl-5-(4-chlorophenyl)-8-nitro-1,2,3,4-tetrahydro-isoquinoline mp 162-163° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05917053 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-6da1b13d12dc4441add099efb4d7deaa |
| Source note | uspto-grants-1999_06 |