HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → Methyl 3-(4,4-dimethyl-thiochroman-6-yl)propiolate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | 6-Ethynyl-4,4-dimethylthiochroman | HCID 10932539 | — |
| Reactant | Ethyl 3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)propiolate | HCID 11000580 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | Methyl 3-(4,4-dimethyl-thiochroman-6-yl)propiolate | HCID 18357955 | — |
Reaction Steps
Employing the same general procedure as used for the preparation of ethyl 3-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)propiolate (Compound A), but instead using 2.0 g (10 mmols) of (4,4-dimethyl-thiochroman-6-yl)ethyne, 2 g (21.3 mmols) of methylchloroformate and 11 mmols of n-butyl lithium the title compound was obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05917082 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-f72d066fe2ec4f3383d28f6fbe4dd69f |
| Source note | uspto-grants-1999_06 |