HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic anhydride → 3-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)-2,2-dimethyl-propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 2-[4-(2-Carboxy-2-methylpropyl)phenoxymethyl]benzoic acid | HCID 67598632 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)-2,2-dimethyl-propanoic acid | HCID 15783179 | 19.6% |
Reaction Steps
A slurry of 2-[4-(2-carboxy-2-methylpropyl)phenoxymethyl]benzoic acid (15.9 g) in 200 ml dry dichloromethane was treated dropwise with 12.5 ml trifluoroacetic anhydride then heated to reflux for 5 hours. Evaporation left an oil which was purified by HPLC (20:1 dichloromethane-methanol) to give 2.95 g of 3-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)-2,2-dimethyl-propanoic acid a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05917057 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-84cf391e3f7f4572ad15724bc1045700 |
| Source note | uspto-grants-1999_06 |