Hydrochloric Acid → Z-Leu-Asp(OtBu)-Leu-OH

참여 물질

역할	이름	HCID	투입량
반응물	Hydrochloric Acid	HCID 313	—
반응물	Sodium Bicarbonate	HCID 516892	—
반응물	N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester	HCID 11089751	—
반응물	H-Asp(OtBu)-Leu-OH	HCID 131721134	—
용매	Water	HCID 962	—
용매	1,4-Dioxane	HCID 31275	—
생성물	Z-Leu-Asp(OtBu)-Leu-OH	HCID 131721135	80.7%

반응 단계

The H-Asp(OtBu)-Leu-OH (3.02 g), sodium bicarbonate (1.68 g), and 30 mL of water were mixed to give a mixture of pH 8. Z-Leu-OSu (3.63 g) in dioxane (30 mL) was added to the mixture and was stirred at room temp for 2 h. The reaction mixture was acidified by addition of conc. HCl to pH 1.0, then was extracted with ethyl acetate (30 mL×3). The combined extracts were dried over Na2SO4, filtered, and concentrated. The crude product was dissolved in methanol and chromatographed on a column of Sephadex™ LH20 to yield Z-Leu-Asp(OtBu)-Leu-OH as a foamy solid (4.43 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05876945
출처 데이터셋	uspto-grants-1999_03
ORD ID	ord-7345b48b96344ac08a6f03e84bb02d7a
출처 메모	uspto-grants-1999_03