Potassium Carbonate → HCID 15790823, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.3 g (14.3 mmol) of 3-(4-cyano-2,5-difluoro-phenyl)-6-trifluoromethyl-pyrimidin-4-one (cf. Example 1), 1.6 g (14.3 mmol) of ethanesulphonamide, 2.0 g (14.3 mmol) of potassium carbonate and 50 ml of dimethyl sulphoxide is stirred at 60° C. for 6 hours and then concentrated under reduced pressure. The residue is taken up in water and, after acidification, shaken with methylene chloride. The organic phase is dried with sodium sulphate and filtered. The filtrate is concentrated, and the crude product obtained as residue is purified by column chromatography (silica gel, ethyl acetate/chloroform, 1:1 by volume). 100 mg (2% of theory) of 3-(4-cyano-5-ethylsulphonylamino-2-fluoro-phenyl)-6-trifluoromethyl-pyrimidin-4-one of melting point 170° C. are obtained.

Provenance & Evidence