Benzyl Bromide → HCID 54017981, compound

Participants

Reaction Steps

0.5 g of 7-(4,6-dimethoxypyrimidin-2-yl)-7-hydroxy-4-phenylfuro[3,4-b]pyridin-5(7H)one was dissolved in 10 ml of N,N-dimethylformamide, and 0.2 g of potassium carbonate was added thereto. Then, the reaction solution was stirred sufficiently. 0.23 g of benzyl bromide was added dropwise to the reaction solution at room temperature, and the reaction solution was stirred for one day. The reaction solution was poured into ice water and extracted with ethyl acetate. The extract was sufficiently washed with water and then dried over anhydrous magnesium sulfate. The solvent was distilled off, and the resulting crude crystals were washed with isopropyl ether to obtain 0.5 g (yield 80%) of the desired compound. m.p.: 124°-126° C.

Provenance & Evidence