HRID1417183

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)O)cc1

HCID10496574

未命名化合物

结构：CC(C)(C)OC(=O)CN1CCN[C@@H](CCCCNC(=O)OC(C)(C)C)C1=O.O=C(O)C(=O)O

HCID70045923

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)N2CCN(CC(=O)OC(C)(C)C)C(=O)[C@@H]2CCCCNC(=O)OC(C)(C)C)cc1

HCID11061479

未命名化合物

PROCEDURE

实验过程

In substantially the same manner as in Reference Example 2, the title compound was synthesized using (S)-3-(4-t-butoxycarbonylaminobutyl)-2-oxopiperazine-1-acetic acid t-butyl ester oxalate and N-Z-Tyr(OMe)-OH.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9d58bc1121e844d68634eaf66d50a93d
来源数据集: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05876756
来源说明: uspto-grants-1999_03

反应 SMILES

C(O)(=O)C(O)=O.[C:7]([O:11][C:12](=[O:33])[CH2:13][N:14]1[CH2:19][CH2:18][NH:17][C@@H:16]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C:15]1=[O:32])([CH3:10])([CH3:9])[CH3:8].[NH:34]([C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])[C@H:35]([C:45](O)=[O:46])[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[CH:39][CH:38]=1>>[C:7]([O:11][C:12](=[O:33])[CH2:13][N:14]1[CH2:19][CH2:18][N:17]([C:45](=[O:46])[C@@H:35]([NH:34][C:48]([O:50][CH2:51][C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)=[O:49])[CH2:36][C:37]2[CH:38]=[CH:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=2)[C@@H:16]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C:15]1=[O:32])([CH3:10])([CH3:8])[CH3:9]