Ethyl isothiocyanatoformate → N-(4-t-butoxycarbonylphenyl)-N'-ethoxycarbonyl thiourea

Participants

Reaction Steps

In 150 ml of isopropyl ether was dissolved 13.51 g of 4-amino-benzoic acid t-butyl ester. To the solution was added, while stirring at room temperature, 9.83 g of ethoxycarbonyl isothiocyanate. The mixture was stirred for two hours, the resulting crystalline precipitate was collected by filtration and recrystallizated from isopropyl ether to give 21.83 g of the title compound as colorless needles.

Provenance & Evidence