HCID 178502575, compound → HCID 178502574, compound

Participants

Reaction Steps

In 25 ml of trifluoroacetic acid was dissolved 9.2 g of N-(4-t-butoxycarbonylphenyl)-N'-methoxycarbonyloxyguanidine produced in Reference Example 64. The solution was stirred for two hours at room temperature, then concentrated under reduced pressure, to which was added 100 mL of water was added to ther esidue and the pH of the solution was adjusted to 6 using sodium hydrogen carbonate. The resulting crystalline precipitate was collected by filtration and recrystallizated from tetrahydrofuran-ethyl acetate to afford 4.53 g of the title compound as a colorless crystalline product.

Provenance & Evidence