tert-Butyl bromoacetate → HCID 22122248, compound

HRID 1417220Notes

Reaction equation

HRID 1417220 reaction equation
[O:1]=[C:2]1[C:7](=[O:8])[NH:6][CH2:5][CH2:4][N:3]1[CH2:9][CH2:10][CH2:11][C:12]([O:14][CH:15]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13].Br[CH2:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31]>>[C:33]([O:32][C:30]([CH2:29][N:6]1[CH2:5][CH2:4][N:3]([CH2:9][CH2:10][CH2:11][C:12]([O:14][CH:15]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:13])[C:2](=[O:1])[C:7]1=[O:8])=[O:31])([CH3:36])([CH3:35])[CH3:34]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 22122133HCID 22122133, compound

Product 1

HCID 22122248HCID 22122248, compound

Procedure

With 1.30 g of diphenylmethyl 4-(2,3-dioxopiperazin-1-yl)butyrate was reacted 0.63 ml of tert-butyl bromoacetate by the same method as in Reference Example 12 to obtain 1.48 g of diphenylmethyl 4-(4-tert-butoxycarbonylmethyl-2,3-dioxopiperazin-1-yl)butyrate as a yellow oil.

Sources & evidence

ORD record
ord-9b7261be04ae448aae93064adc37879c
Source dataset
uspto-grants-1999_03
Patent number
US05877174

Reaction notes

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