Hydrochloric Acid → HCID 86753756, compound

Participants

Reaction Steps

A mixture of 1.05 g of methyl [4-[3-(4-benzyloxycarbonylamidinophenoxy) propyl]-2,3-dioxopiperazin-1yl]acetate, 0.35 g of 5% palladium-carbon, 0.39 ml of 6N hydrochloric acid and 15 ml of methanol was subjected to hydrogenation at ordinary temperature and atmospheric pressure for 3 hours. Then, the pallasium-carbon was filtered off and the solvent was distilled off under reduced pressure to obtain 0.8 g of methyl [4-[3-(4-amidinophenoxy)propyl]-2,3-dioxopiperazin-1yl]acetate hydrochloride. The compound obtained was dissolved in 14 ml of 6N hydrochloric acid and the resulting solution was refluxed for 1 hour, after which the solvent was distilled off under reduced pressure to obtain 0.6 g of [4-[3-(4-amidinophenoxy)-propyl]-2,3-dioxopiperazin-1-yl]acetic acid hydro-chloride as colorless crystals.

Provenance & Evidence