Triethylamine → 2-(2,2,2-Trifluoroethyl)-2-(trifluoromethyl)-1,3-benzodioxole

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Reaction Steps

306.5 g of 2-(1-chloro-2,2,2-trifluoroethyl)-2-trifluoromethyl-1,3-benzodioxole from Example 2a were dissolved in 500 ml of THF, and 101 g of triethylamine and 30 g of palladium on carbon (5% by weight) were added. Hydrogenation was then carried out with 100 bar of hydrogen at 110° C. for 48 h. The mixture was then filtered, the solvent stripped off in vacuo and the residue subjected to fractional distillation in vacuo. The yield was 126 g (46% of theory) and the boiling point was 60° C. at 10 mbar. The NMR spectra showed the following characteristic absorption: 19F-NMR: -59.0 and -84.6 ppm; 1H-NMR: 3.02 ppm.

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