Thiourea → HCID 21845597, compound

HRID 1417298Notes

Reaction equation

HRID 1417298 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=O.[NH2:15][C:16]([NH2:18])=[S:17]>CO>[BrH:1].[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([C:3]2[N:15]=[C:16]([NH2:18])[S:17][CH:2]=2)[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

Product 1

HCID 21845597HCID 21845597, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 8.1 g of 2-bromo-1-(3-trifluoromethyl-phenyl)-ethanone in 70 ml of methanol was treated at room temperature with 3.2 g of thiourea and boiled for 1 hour. 4.1 g of 4-(3-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C.

Workup

  1. custom4.1 g of 4-(3-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals

Sources & evidence

ORD record
ord-284f4188d0ab407bb6e61b4724517e17
Source dataset
uspto-grants-1999_03
Patent number
US05877193

Reaction notes

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