HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1417300Generated: October 26, 2026
1-(3-(Benzyloxy)phenyl)-2-bromoethanone → 4-[3-(Benzyloxy)phenyl]-1,3-thiazol-2-amine hydrobromide
https://huagongshe.com/reaction/1417300
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(3-(Benzyloxy)phenyl)-2-bromoethanone | HCID 88031 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[3-(Benzyloxy)phenyl]-1,3-thiazol-2-amine hydrobromide | HCID 16495478 | — |
Reaction Steps
A solution of 22.5 g of 2-bromo-1-(3-benzyloxy-phenyl)-ethanone in 150 ml of methanol was treated at room temperature with 7.8 g of thiourea and boiled for 1 hour. 16.1 g of 4-(3-benzyloxy-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05877193 |
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| Source dataset | uspto-grants-1999_03 |
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| ORD ID | ord-33a4e5198fe144f9a1a584fb82b70782 |
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| Source note | uspto-grants-1999_03 |
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