Hydrazine → HCID 16105140, compound

HRID 1417310Notes

Reaction equation

HRID 1417310 reaction equation
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].NN>C(O)C>[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 161051422-[4-(4-Nitrophenoxy)butyl]-1H-isoindole-1,3(2H)-dione

Product 1

HCID 16105140HCID 16105140, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 62.6 g of 2-[4-(4-nitrophenoxy)butyl]-1H-isoindole-1,3(2H)-dione (Example 33) in one liter of ethanol is treated with 6.5 ml of hydrazine, and the mixture then stirred at reflux for 18 hours. After cooling to room temperature, the precipitate is collected, washed with 250 ml of hot 2.5N HCl, and 200 ml of hot H2O. The combined acid and water washes are taken to dryness to obtain the hydrochloride salt of the title compound. Mass spectrometry shows the presence of the title compound. The compound is utilized directly without further purification.

Workup

  1. temperatureat reflux for 18 hours
  2. customthe precipitate is collected
  3. washwashed with 250 ml of hot 2.5N HCl, and 200 ml of hot H2O

Sources & evidence

ORD record
ord-5502cb4ccd9c4643b946cdf232f7947b
Source dataset
uspto-grants-1999_03
Patent number
US05877196

Reaction notes

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