Acetic Acid → HCID 67598186, compound

Participants

Reaction Steps

To a solution of 17.7 g of 2-[4-(4-amino-phenoxy)butyl]-1H-isoindole-1,3(2H)-dione (Example 37) in a mixture of 250 ml of acetic acid and 80 ml of triethylorthoformate is added 7.0 g of sodium azide and the mixture then stirred and heated on the steam bath for 4 hours. Concentration to dryness in vacuo leaves a residue that is triturated with 250 ml of water. The insolubles are collected, washed with water, and dried. Recrystallization from ethanol gives the title compound, m.p. 143°-145° C.

Provenance & Evidence