Hydrazine → 1-[4-(4-Aminobutoxy)phenyl]ethanone

HRID 1417317Notes

Reaction equation

HRID 1417317 reaction equation
[C:1]([C:4]1[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].NN>C(O)C>[NH2:13][CH2:12][CH2:11][CH2:10][CH2:9][O:8][C:7]1[CH:6]=[CH:5][C:4]([C:1](=[O:3])[CH3:2])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 675980872-[4-(4-Acetylphenoxy)butyl]-1H-isoindole-1,3(2H)-dione

Product 1

HCID 538579851-[4-(4-Aminobutoxy)phenyl]ethanone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 13.5 g of 2-[4-(4-acetyl-phenoxy)butyl]-1H-isoindole-1,3(2H)-dione in 500 ml of ethanol is treated with 1.4 ml of anhydrous hydrazine, and the mixture stirred at reflux for 9 hours. After cooling to room temperature, the precipitate is collected. Concentration of the filtrate gives the crude title compound, which is used directly for further synthesis.

Workup

  1. temperatureat reflux for 9 hours
  2. customthe precipitate is collected

Sources & evidence

ORD record
ord-6cbea0b89fcd4d0aaed11e41adb43517
Source dataset
uspto-grants-1999_03
Patent number
US05877196

Reaction notes

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